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肠道微生物群和围和囊:双向的孟德尔随机化研究

Rong-Chao He¹, Jun He², Hou-Dong Wang²

¹Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.

|September 3, 2025

概括

这项研究揭示了特定的肠道细菌与腹和囊风险有关. 这些发现澄清了肠道微生物群.

科学领域:

胃肠病学和微生物学
遗传流行病学

背景情况:

周围和囊是具有高复发率的疼痛性手术疾病,对患者的生活质量产生重大影响.
之前的研究表明,患有这些疾病的患者的肠道微生物组成有差异,但因果关系尚不清楚.
了解肠道微生物组的作用对于开发有针对性的治疗和预防策略至关重要.

研究的目的:

调查特定肠道微生物种群与患上围和囊的风险之间的潜在因果关系.
区分肠道微生物对这两种不同但相关的外科疾病的影响.

主要方法:

使用双向双样本孟德尔随机化 (MR) 分析.
来自MiBioGen联盟的肠道微生物群数据和来自MRC IEU开放GWAS项目的结果数据.
作为主要分析,采用逆方差加权 (IVW) 方法,并以强度的敏感性分析为支持.

主要成果:

四种肠道微生物群因果关系与周围风险相关:Eubacterium brachy群 (增加的风险),Ruminococcaceae UCG003,Erysipelatoclostridium和Butyrivibrio (降低的风险).
八种肠道微生物群与尾风险有显著的关联:Catenibacterium和Eubacterium ruminantium群 (风险增加),而Haemophilus,Alloprevotella,Ruminiclostridium5,ErysipelotrichaceaeUCG003,Butyrivibrio和Escherichia- Shigella则表现出一种保护作用.
敏感性分析证实了这些发现的稳定性,反向MR分析排除了反向因果关系.

结论:

这项研究提供了第一个关于特定肠道细菌和围感染之间的因果关系的MR证据.
鉴定出与周围腹和囊风险增加或降低相关的独特肠道微生物特征.
这些发现增强了对肠道微生物群在这些疾病发病过程中的作用的理解,并可能为未来的治疗方法提供信息.

关键词:

孟德尔随机化阴道肠道微生物群周围

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