血尿素度与糖尿病足之间的关联:基于NHANES的回顾性横截面研究
1Guangzhou University of Chinese Medicine, Guangzhou, China.
Medicine
|September 3, 2025
概括
在40岁以上的成年人中,较高的血尿 (BUN) 水平与糖尿病足 (DFU) 的风险增加有关. 监测BUN可能有助于早期发现和干预DFU.
科学领域:
- 内分泌学
- 肝脏病学
- 公共卫生
背景情况:
- 糖尿病足 (DFU) 是糖尿病的一个重要并发症.
- 血尿酸 (BUN) 水平升高可能表明功能障碍,这是糖尿病患者常见的并发症.
- 了解BUN和DFU之间的关系对于患者管理至关重要.
研究的目的:
- 调查40岁以上美国成年人血尿酸 (BUN) 和糖尿病足 (DFU) 的患病率之间的联系.
- 确定关系的性质 (线性,非线性) 并确定潜在的值效应.
主要方法:
- 对国家健康和营养检查调查 (NHANES) 的1673名参与者的数据分析 (1999-2004).
- 开发四种物流回归模型来评估BUN和DFU的相关性.
- 使用平滑曲线和值效应分析.
- 分组分析按年龄,性别,BMI和HbA1C分层.
主要成果:
- 总共分析了1622名成年人,其中131人 (8. 07%) 患有DFU.
- 最高的BUN水平与增加的DFU风险显著相关 (OR=3. 56,P=. 007).
- 滑曲线显示了BUN和DFU之间的线性相关性,其值为5.4 mmol/L.
结论:
- 血尿酸含量与糖尿病足风险之间存在正线性相关性.
- 定期监测糖尿病患者的BUN可以促进早期诊断和干预DFU.
- 这些发现凸显了BUN作为DFU风险评估的潜在生物标志物.
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