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无线声压电导体与对齐的纳米纤维用于神经再生

Sera Jeon¹, Dabin Kim¹, Min-Young Jo²

¹Department of Materials Science and Engineering, Center for Human-oriented Triboelectric Energy Harvesting, Yonsei University, Seoul, 03722, Republic of Korea.

Advanced materials (Deerfield Beach, Fla.)

|September 3, 2025

概括

一个新的超声响应神经管道 (APNF-NGC) 促进了周围神经的再生. 这种装置提供电刺激和结构支持,

科学领域:

生物材料科学
神经工程
复原医学

背景情况:

周围神经损伤 (PNI) 导致显著的运动和感官功能障碍.
目前的治疗方法如自体移植有其局限性,包括捐赠地点的发病率和可用性.
需要先进的神经引导管道来有效地再生外围神经.

研究的目的:

开发和评估用于外围神经再生的响应超声波的平电纳米纤维神经引导管道 (APNF-NGC).
评估APNF-NGC提供结构支持和无线电刺激的能力.
在外围神经损伤的临床前模型中,比较APNF- NGC与自体移植的疗效.

主要方法:

使用带有聚乙烯糖醇 (PEG) 的电聚乳酸 (PLLA) 纳米纤维制造APNF-NGC.
管道的异构结构,剪切压电和声压电响应的特征.
在8毫米老鼠坐骨神经缺陷模型中的体内评估,通过行为,运动功能和组织学分析来评估神经再生.

主要成果:

在超声波激活时,APNF-NGC显示了剪切压电,并产生了轴向电场.
增强了PEG的机械性能,结晶性和水友性,改善了生物相容性和压电反应.
通过综合功能和组织学评估,体内研究表明,APNF- NGC实现了与自体移植相当的神经再生.

结论:

开发的APNF-NGC作为一个双功能平台,将物理引导与无线电刺激相结合,用于外围神经的再生.
这项技术为自体移植提供了一个有前途的替代方案,特别是在治疗长期外围神经损伤方面.
APNF-NGC在神经组织工程和PNI的临床管理方面提供了潜在的突破.

关键词:

电纳米纤维神经引导管道周围神经损伤压电聚合物可再生脚手架

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