基于损伤的脱节解释了多发性硬化症的认知结果
Jonadab Dos Santos Silva1,2,3, Claudia C F Vasconcelos4, Carina T Spedo5
1Postgraduate Program in Neurology, Universidade Federal Fluminense, Niterói, Brazil.
概括
大脑病变的断开,不仅仅是病变负载,在多发性硬化症 (MS) 中显著影响认知功能. 脱节组映射揭示了与多发性硬化患者处理速度,语言和视觉空间记忆缺陷相关的特定白质区域.
科学领域:
- 神经科学
- 神经学
- 医学成像
背景情况:
- 认知障碍是多发性硬化症 (MS) 的重要和致残的症状.
- 传统的病变负担测量不能完全解释MS患者所观察到的认知缺陷的程度.
研究的目的:
- 调查是否脱节,代表病变的间接影响,比较病变负载更好地解释MS的多域认知缺陷.
- 确定与MS认知障碍相关的特定白质路径.
主要方法:
- 三十名患有多发性硬化症的成年人接受了认知评估,包括处理速度 (符号数字模式测试; SDMT),口头记忆 (加利福尼亚口头学习测试-II; CVLT-II) 和视觉空间记忆 (简要视觉空间记忆测试-修订; BVMT-R).
- 从3次特斯拉液体减弱反转恢复MRI扫描中进行了细分.
- 为了分析与认知表现的关联,生成了管道特异性断开和语音断开图.
主要成果:
- 在MS队列中,所有评估领域的认知功能都受损 (p < 0. 001).
- 脱节体积显著预测认知能力 (β = -0.41, p = 0.004),超过损伤体积作为决定因素.
- 特定的白质通道与明显的认知缺陷有关:SDMT的左侧环膜,CVLT-II的左侧弧形环膜和BVMT-R的右侧环膜.
结论:
- 在MS相关的认知障碍中,损伤驱动的脱节比单独的损伤负担更重要.
- 脱节组映射提供了一种有价值的方法来了解MS认知缺陷的网络层面机制.
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