儿童多系统炎症综合征中的2D斑点跟踪应变心声学:MUSIC研究的多中心分析
Francesca Sperotto1, Valiantsina Kazlova2, Felicia L Trachtenberg2
1Department of Cardiology, Boston Children's Hospital, Harvard Medical School, MA (F.S., A. Dionne, J.W.N., K.G.F.).
儿童多系统炎症综合征 (MIS-C) 可能导致亚临床心室功能障碍. 在MIS- C患者中,异常的左心室 (LV) 应变参数,包括4室LV纵向应变和中心室LV周围应变,与不良心血管结局有关.
科学领域:
- 儿童心脏病学
- 心血管成像
- 儿童重症监护
背景情况:
- 儿童多系统炎症综合征 (MIS-C) 可能导致心脏并发症.
- 亚临床腹腔功能障碍是MIS-C的一个问题,但数据有限.
- 2D-speckle追踪回声可以检测心室功能障碍.
研究的目的:
- 在MIS-C患者中调查左心室 (LV) 应变参数.
- 评估LV菌株与住院心血管不良结果之间的关联.
主要方法:
- 一个32中心的住院MIS-C患者的队列研究.
- 使用二维光斑追踪对心声回声图进行分析.
- 概括估计方程建模以将LV菌株与不良结果联系起来.
主要成果:
- 45% 的 MIS- C 患者表现出压抑的 LV 菌株 (4 腔 LV 纵向菌株或中腔 LV 周围菌株).
- 异常的 LV 应变与住院心血管不良结果独立相关.
- 具体的压力参数如4CH-LVLS,中期LVCS和入院时的早期扩张纵向压力率是显著的预测因素.
结论:
- 大约一半的MIS-C患者在住院期间出现异常的LV应变.
- 抗血压参数与不良心血管结果独立相关.
- 这些发现可以帮助早期描述和预测MIS-C.
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