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Updated: Sep 9, 2025

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使用结有机框架 (HOFs) 选择性检测抗生素:DFT机制分析的见解

Malabika Ghosh¹, Uddipan Dasgupta¹, Prashanth Venkatesan²

¹Amity Institute of Nanotechnology, Amity University Kolkata, Major Arterial Road, AA II, Newtown, Kolkata, West Bengal, 700135, India. adchowdhury@kol.amity.edu.

Journal of materials chemistry. B

|September 3, 2025

概括

一种新型传感材料使用光激活机制检测ENR抗生素. 这种具有成本效益的方法可以在各种复杂的样本中进行超敏感检测.

科学领域:

材料科学
分析化学
纳米技术

背景情况:

开发无毒,具有成本效益的光传感器至关重要.
与结合的半孔有机框架 (HOF) 提供了敏感检测的潜力.
在环境和生物样本中检测抗生素残留物是一个重大问题.

研究的目的:

开发一个简单的合成技术,用于 mesoporous HOFs.
创建一个超灵敏的光传感器,用于Enrofloxacin (ENR).
研究传感机制并验证其在复杂矩阵中的性能.

主要方法:

与结合的半孔有机框架 (HOF) 的合成.
通过Cu2+离子灭光,并在ENR添加后恢复光.
用于机制验证的动力和密度功能理论 (DFT) 研究.
在增缓冲剂,血清,牛奶和河水样本中分析传感器性能.

主要成果:

HOF光被Cu2+灭,并通过竞争性结合被ENR恢复.
在0.011.0μM的线性范围内达到70nM的检测极限 (LOD).
证明了更广泛的非线性检测范围,最高可达50μM.
在具有高灵敏度和选择性的复杂生物和环境样本中成功验证了传感器性能.

结论:

开发的基于HOF的传感器为ENR检测提供了强大而超灵敏的平台.
竞争的约束机制已经得到充分理解和验证.
这种传感器在现实世界样本分析中具有很大的应用潜力.

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