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Updated: Sep 9, 2025

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis
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Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis

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各种类型的酸脱酶与酸的结合差异:来自in silico模拟的见解

Na Zhai1, Cong Zhou1, Liangliang Cheng1

  • 1Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China.

Pest management science
|September 3, 2025
PubMed
概括

了解酸脱酶 (SDH) 抑制剂的选择性对于开发新的杀菌剂至关重要. 这项研究采用了酸方法,揭示了fluksapyroxad (FLX) 如何在不同物种中与SDH结合,突出显示了酸

关键词:
结合的自由能量绑定模式流动性酸盐分子动力学预测受体结构酸脱酶

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Pyruvate Oxidation01:15

Pyruvate Oxidation

After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
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