基于纳米配方的药物输送系统用于治疗胃癌:最近的发展和未来的前景
Jiale Zou1,2, Siwen Chen1, Wenhui Liu1
1Department of Gastroenterology, The Second Medical Center, National Clinical Research Center for Geriatrics Diseases, Chinese PLA General Hospital, Beijing 100853, P. R. China. xusp301@163.com.
Nanoscale horizons
|September 3, 2025
概括
纳米材料为胃癌 (GC) 治疗提供了有前途的向治疗,提高了疗效并减少了副作用. 本综述涵盖了各种纳米配方及其在各种GC治疗策略中的应用.
科学领域:
- 癌症学
- 纳米技术
- 材料科学
背景情况:
- 胃癌仍然是全球癌症死亡的主要原因.
- 尽管取得了进展,但目前的GC疗法仍未达到最佳治疗效果.
- 纳米材料正在成为针对癌症治疗的有效工具.
研究的目的:
- 对胃癌 (GC) 治疗的纳米配方进行全面审查.
- 研究纳米材料在各种GC治疗策略中的应用.
- 讨论基于纳米的GC疗法的设计原则,挑战和未来前景.
主要方法:
- 主要纳米配方类型的审查:脂质体,基于白蛋白的NP,基于聚合物的NP,无机NP和来自细胞的纳米材料.
- 对化学疗法,放射疗法,免疫疗法,基因疗法,光疗法和结合疗法中纳米配方的检查.
- 在GC处理中分析纳米配方的设计概念和基本原则.
主要成果:
- 各种纳米配方表明在GC中具有向药物递送的潜力.
- 在多种GC治疗方式中探索纳米配方.
- 关键设计原则有助于改善治疗效果和降低毒性.
结论:
- 纳米配方代表了胃癌 (GC) 治疗策略的重大进步.
- 通过纳米材料的向输送提高了治疗效果,并将副作用降到最低.
- 对纳米配方设计和应用的持续研究有望克服GC治疗挑战.
相关概念视频
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Drug Delivery: Overview
422
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
422
Peptic Ulcer Disease IV: Management
145
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
145
Cancer Vaccines
509
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
509
Drug Delivery: Enteral Route
709
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
709
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
595
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
595


