相关实验视频
Updated: Sep 9, 2025

04:23
Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
2.3K
输血的特征和与肝细胞瘤切除中的瘤结果的关联
Stephanie F Polites1, Jennifer H Aldrink2, Timothy B Lautz3
1Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Pediatric blood & cancer
|September 3, 2025
概括
在患有肝细胞瘤 (HB) 的儿童中,手术内输血 (IBT) 与死亡风险增加有关. 这项研究表明IBT可能会导致凝血病,并强调在儿童HB患者中需要优化输血策略.
科学领域:
- 儿童瘤学
- 输血医学
- 手术的结果
背景情况:
- 患有肝细胞瘤 (HB) 的儿童经常接受手术内输血 (IBT),但对生存的影响尚不清楚.
- 仅有有限的数据来指导这种脆弱的儿科患者的输血实践.
研究的目的:
- 调查儿科肝细胞瘤 (HB) 患者的手术内输血 (IBT) 和生存结果之间的关联.
主要方法:
- 一项多中心的回顾性观察研究包括338名患有HB的儿科患者 (< 18岁),这些患者接受了初级瘤切除或肝移植 (2010 - 2019年).
- 为了评估IBT与复发和死亡的关联,使用了倾向分数重权 (PSR) 考克斯比例危险回归分析.
主要成果:
- 在338名患者中,76%接受IBT,主要是红细胞 (pRBC).
- IBT与更高的治疗前疾病程度和复杂切除有关,尽管这些差异通过倾向性评分权重减轻.
- 接受IBT的患者手术后血红蛋白水平较高,需要更多的血/血小板输血. 关键的是,IBT与死亡风险增加了2. 35倍 (PSR HR2. 35,95% CI为1. 10-5. 02),而复发率没有显著差异.
结论:
- 在儿科肝细胞瘤 (HB) 患者的手术内输血 (IBT) 与死亡风险增加有关.
- 结果表明由于以pRBC为重点的方法可能导致不必要的输血和凝血病.
- 需要最佳的输血策略,以尽量减少输血并改善儿科HB患者的治疗结果.
相关概念视频
Blood Transfusion
799
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
799
Bone Marrow Sampling and Transplants
493
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
493
Blood Transfusion and Agglutination
11.2K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
11.2K
Tissue Transplantation
519
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
519
Kidney Transplant II: Surgical Procedure
75
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
75
Kidney Transplant I: Introduction
60
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60

