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Updated: Sep 9, 2025

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发现以p53-MDM2作为抗癌剂的混合化合物

Mai A Mansour1, Ghaneya S Hassan1,2, Maiy Y Jaballah3

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Badr University in Cairo, Badr City, Cairo, Egypt.

Archiv der Pharmazie
|September 3, 2025
PubMed
概括

研究人员开发了新型的pyrazoline化合物来抑制p53-MDM2相互作用,恢复p53的瘤抑制功能,用于潜在的抗癌疗法. 化合物6d显示出显著的抗增殖活性和对癌细胞的选择性.

关键词:
MDM2 的抑制射线衍射抗癌活性p53与MDM2的相互作用合成野生类型的p53

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