这是值得的吗? 来自超过650名美国和国际化学预防试验参与者的反应数据
在PubMed上查看摘要
概括
此摘要是机器生成的。在早期化疗预防试验中,参与者的满意度总体很高 (85%). 然而,黑人/亚裔/>1种族参与者和经历不良事件或早期终止的参与者报告的满意度较低,突出了试验改进的领域.
科学领域
- 临床试验
- 癌症预防研究
- 患者报告的结果
背景情况
- 早期化学预防试验对于开发新的癌症预防策略至关重要.
- 了解参与者的满意度对于改善试验积累,保留和坚持至关重要.
- 之前的研究还没有在这个特定的试验环境中广泛探索满意度因素.
研究的目的
- 评估早期化疗预防试验参与者的满意度.
- 确定与参与者满意度相关的人口和试验相关因素.
主要方法
- 癌症预防网络的13项早期化疗预防试验 (2006-2021) 的数据分析.
- 管理的5项"这是值得的吗?" (WIWI) 调查问卷以评估整体满意度.
- 统计分析以确定652名参与者在不同的人口结构和试验经验中的整体满意度预测因素.
主要成果
- 总体而言,有85%的参与者表示满意.
- 与白人,非西班牙裔/拉丁裔参与者相比,较低的满意度与黑人/亚裔/>1种族相关 (OR2. 96,P<0. 001).
- 不满意度的增加与介入前的不良事件 (OR 1. 9, P=0. 012),介入期间的长期不良事件 (OR 1. 8, P=0. 024) 和早期结束试验 (OR 7. 4, P< 0. 001) 有关.
结论
- 虽然总体满意度很高,但特定的子组和经验会对参与者在化疗预防试验中的满意度产生负面影响.
- 结果表明需要解决不良事件和试验持续时间,以改善参与者的体验.
- 提高满意度可以提高未来的试验积累,保留,坚持和癌症预防研究的多样性.
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