Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Hydrocarbon Organic Cage-Based Porous Liquid for Ethylene/Ethane Separation.

Journal of the American Chemical Society·2026
Same author

Associations of Solid Fuel Use and Circadian Rhythm Syndrome With Physical Function and Muscle Strength in Middle-Aged and Older Adults: Nationwide Cohort Study in China.

JMIR aging·2026
Same author

Regular Aerobic Exercise Can Effectively Ameliorate the Skeletal Muscle and Mitochondrial Function Impairments Caused by <i>bves</i> Deficiency in Zebrafish.

International journal of molecular sciences·2026
Same author

Nanostructured coatings on soft-polymer based neural probes for addressing neuroinflammation.

Acta biomaterialia·2026
Same author

YOLO11-SBS: leveraging ACE and ORCM to gauge robust and accurate apple counting in complex orchards.

Frontiers in plant science·2026
Same author

Dynamic biomimicry in skin-on-a-chip: multi-scale construction to translational dermatology, drug screening and cosmetic evaluation.

Lab on a chip·2026

相关实验视频

Updated: Sep 9, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

942

一个单细胞的转录形态是老鼠内分泌系统的特征

Ran Wei1, Zhehao Du1, Jue Wang2,3,4

  • 1The State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.

Protein & cell
|September 3, 2025
PubMed
概括

通过激活特定的细胞通路并增加免疫细胞透, 衰老会损害内分泌器官. 针对免疫反应可以抵消内分泌系统的衰老效应.

关键词:
年龄增长内分泌系统免疫透一个细胞RNA-seq

更多相关视频

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells
10:05

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells

Published on: September 30, 2018

11.2K
Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
08:23

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

17.5K

相关实验视频

Last Updated: Sep 9, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

942
Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells
10:05

Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells

Published on: September 30, 2018

11.2K
Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
08:23

Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes

Published on: December 28, 2011

17.5K

科学领域:

  • 内分泌学
  • 免疫学
  • 老年学

背景情况:

  • 虽然内分泌系统对平衡至关重要,但细胞层面的衰老过程尚不清楚.
  • 衰老会影响各种器官,但对内分泌器官衰老缺乏全面的单细胞分析.

研究的目的:

  • 阐明导致内分泌系统衰老的细胞和分子机制.
  • 在多个内分泌器官中识别细胞类型特定的衰老特征.
  • 研究免疫透在内分泌衰老中的作用.

主要方法:

  • 从年轻和老鼠的八个内分泌器官单细胞RNA测序.
  • 对细胞类型特定的基因表达,衰老途径和免疫反应的分析.
  • 机器学习可以识别新的衰老生物标志物.

主要成果:

  • 衰老会激活特定的途径,如蛋白质稳定性丧失,基因组不稳定性和反应性氧物种 (ROS).
  • 功能性内分泌细胞显示基因网络受损,免疫透增加,以及蛋白质反应展开 (UPR).
  • 耗尽的T细胞释放GZMK,激活MHC-I-UPR轴; CD59被确定为衰老特征.
  • 性别特定的器官表现出增强的免疫反应,卵巢显示出增加的ROS和丸受损的DNA修复.

结论:

  • 由耗尽的T细胞驱动的免疫透是内分泌衰老的潜在驱动因素.
  • 细胞类型特定的衰老机制在内分泌器官之间有所不同.
  • 这项研究提供了内分泌衰老的高分辨率图,揭示了新的治疗点.