在晚期皮质结膜癌和皮质状细胞癌中使用Cemiplimab:英国病例系列
Mumta Kanda1, Nirodha Jayawickrema1, Indran Davagnanam2
1Adnexal, Moorfields Eye Hospital, London, UK.
Orbit (Amsterdam, Netherlands)
|September 3, 2025
概括
在复杂的病例中,Cemiplimab对晚期状细胞癌 (SCC) 是有前途的,它可能有助于节省眼球和保护视力. 这项研究强调了其在结膜和皮肤SCC的疗效,即使是内干扰.
科学领域:
- 眼科 眼科
- 癌症学
- 皮肤病学
背景情况:
- 晚期状细胞癌 (SCC) 存在重大治疗挑战.
- 一种免疫检查点抑制剂Cemiplimab已经成为一种潜在的治疗选择.
研究的目的:
- 评估塞米普利马布在晚期皮质结膜癌和皮质结膜癌的实际疗效,安全性和结果.
- 评估塞米普利马布作为一种节约眼睛和维护视力治疗的潜力.
主要方法:
- 对9名成年患者的回顾性病例系列,他们接受了对皮质或皮质SCC的治疗.
- 收集患者人口统计数据,先前的治疗,瘤特征,治疗持续时间,不良事件和结果.
主要成果:
- 塞米普利马布的整体反应率为55% (22%完全,33%部分).
- 免疫相关的不良事件是可以控制的 (甲状腺功能低下,肝炎).
- 在有轨入侵和内扩散的复杂病例中有效,具有全球节约治疗的潜力.
结论:
- 塞米普利马布在晚期皮质结膜癌和皮肤结膜癌的治疗中具有节省眼球和保护视力的潜力.
- 它在复杂的病例中有效,包括内干扰或围神经扩散病例.
- 这是迄今为止关于塞米普利马布治疗结膜SCC的最大病例系列.
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