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通过饮食暴露于环境剂量诱导小鼠通过P-AMPK抑制和随后的纯素代谢失调而导致脏损伤

Wen Xie¹, Yajing Zhang¹, Yu He¹

¹Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.

Environmental science & technology

|September 3, 2025

概括

长期接触常见的杀虫剂伊米达克洛普里德 (IMI) 通过破坏细胞能量和增加氧化应激会损害脏健康. 这项研究显示,IMI

科学领域:

环境毒理学
肝脏病学
分子生物学

背景情况:

伊米达克洛普里德 (IMI) 是一种在食品中经常检测到的广泛使用的新类杀虫剂.
慢性饮食IMI暴露的长期健康影响和毒机制尚不清楚.

研究的目的:

在小鼠中研究慢性伊米达克洛普里德暴露的毒性.
阐明IMI诱导的损伤的潜在分子机制.

主要方法:

给小鼠食环境相关的IMI剂量 (100和1000微克/公斤/天) 持续24周.
对脏组织进行了毒理学,组织病理学和分子分析.

主要成果:

在老鼠中,慢性IMI暴露导致功能障碍,细胞病理变化和亡的增加.
通过直接结合和间接氧化应激,IMI抑制了AMP激活蛋白激酶 (AMPK) 的活性.
这导致代谢失调,氧化还原失衡,炎症和亡.

结论:

通过AMPK抑制和氧化压力诱导损伤.
这些发现突显了长期使用农药对脏健康的潜在风险.
提高农业工人和消费者对农药使用和食品安全的认识.

关键词:

通过饮食暴露环境相关的剂量伊米达克洛普里德抑制AMPK蛋白的活性精氨酸代谢发生损伤

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