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相关概念视频

Introduction to Hemostasis01:05

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Updated: Sep 9, 2025

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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基于脱细胞外基质和贝粘合蛋白的可吸收粘合复合止血海绵用于内部出血控制

Hyegyo Cha1, Jaeyun Lee1, Dayoon Kang2

  • 1Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.

Advanced healthcare materials
|September 3, 2025
PubMed
概括

结合脱细胞外基质 (dECM) 和贝类粘合蛋白 (MAP) 的新生物灵感海绵显示出优异的静血性能. 与目前的临床血静止剂相比,这些新材料可以改善伤口愈合和减少不良反应.

关键词:
复合海绵脱细胞化细胞外基质早期伤口稳定控制内出血情况贝类粘合蛋白

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科学领域:

  • 生物材料科学
  • 复原医学
  • 外科创新

背景情况:

  • 目前使用的 Surgicel 和 Avitene 等局部止血剂可能会引起血液溶解和炎症等不良反应, 阻碍伤口愈合.
  • 需要先进的静血生物材料,具有强大的湿粘性,适当的降解性和增强的生物相容性,用于内部应用.
  • 生物灵感材料,包括脱细胞化细胞外基质 (dECM) 和贝粘合蛋白 (MAP),由于其固有的生物相容性和粘合性,提供了有前途的替代品.

研究的目的:

  • 开发和评估结合dECM和MAP的复合海绵,以实现有效的内血静止和伤口愈合.
  • 在复合材料中研究dECM和MAP的协同作用,以提高血静效率.
  • 在临床前模型中比较开发的复合血压器与临床使用的药物的性能.

主要方法:

  • 用不同比例的dECM和MAP制造复合海绵.
  • 在体外评估血静性能,血相容性和细胞相容性.
  • 在华法林治疗的老鼠肝损伤模型中进行体内评估,以测量出血时间和血液损失.
  • 组织学分析以评估伤口愈合的结果,包括缩,纤维化和碎片.

主要成果:

  • E50M50配方 (9. 1% dECM, 90. 9% MAP) 显示出最强的静血能力,特别是增强了二次静血.
  • E50M50表现出优异的血液兼容性和细胞兼容性,以及适合早期伤口愈合的降解特征.
  • 与肝损伤模型中的对照组相比,体内研究显示E50M50显著减少了出血时间和血液损失.
  • 组织学检查显示,与Avitene相比,E50M50的早期伤口愈合优异,并显著减少了不良组织反应.

结论:

  • 由dECM和MAP组成的复合海绵是一种有前途的可吸收,粘合性血静止剂,用于控制内部出血.
  • dECM和MAP的协同作用可以提高血静性能和生物相容性.
  • 这些新生物材料有可能改善早期伤口稳定和愈合结果,比现有的止血剂具有优势.