慢性鼻炎的鼻苦味测试:一个试验性概念验证研究
Shankar Ramasundram1, Ramiza Ramza Ramli2, Norasnieda Md Shukri2
1KPJ Johor Specialist Hospital, Johor Bahru, Johor, Malaysia.
概括
使用甲胺 (PTC) 的鼻腔苦味测试显示为一种简单的慢性鼻炎 (CRS) 查工具. 这种方法有效地区分了CRS患者和健康个体,提供了一种新的诊断方法.
科学领域:
- 耳鼻喉科
- 味觉受体研究
- 免疫学
背景情况:
- 鼻腔粘膜中的苦味受体 (T2Rs) 与慢性鼻炎 (CRS) 的严重程度有关.
- 了解T2R功能可能会揭示CRS管理的治疗目标.
研究的目的:
- 探索鼻腔苦味测试作为CRS的查工具.
- 开发一种检测鼻子T2R敏感性的方法.
- 为未来的研究建立一个合适的配体定位.
主要方法:
- 在84名成年人 (42名CRS,42名对照人) 的横截面研究中.
- 评估鼻子葡萄糖和甲 (PTC) 的味道敏感性.
- 使用PTC值和葡萄糖水平的色度和统计分析.
主要成果:
- 在鼻内测试中,0. 13%的PTC稀释是最佳的.
- 在鼻腔苦味测试和CRS状态之间发现了显著的关联 (p < 0. 001).
结论:
- 鼻腔苦味检测是一种简单,廉价的CRS查方法.
- 这项研究为CRS诊断和管理中T2R向的进一步研究提供了基础.
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