IPH5201,一种抗CD39单克隆抗体,作为单疗法或与杜尔瓦卢马布联合治疗晚期固体瘤
John Powderly1, Martina Imbimbo2, Antoine Italiano3
1Carolina BioOncology Institute, Huntersville, NC, United States.
Cancer research communications
|September 3, 2025
概括
在晚期固体瘤患者中,IPH5201是一种集群分化39 (CD39) 抑制剂,耐受性良好. 这种药物具有药理活性,减少了瘤CD39活性,并显示了疾病稳定性的潜力.
科学领域:
- 癌症学
- 免疫学
- 药理学
背景情况:
- 通过将免疫刺激性ATP转化为免疫抑制性腺,在瘤微环境中发挥关键作用.
- 抑制CD39活性可以增强抗瘤免疫力,并改善晚期固体瘤患者的治疗结果.
研究的目的:
- 评估新型CD39抑制剂IPH5201的安全性,耐受性和初步疗效.
- 在先进的固体瘤患者中,评估IPH5201作为单一治疗和与杜尔瓦卢马布 (抗PD- L1) 联合治疗.
主要方法:
- 这是一项首次对人类进行的第一阶段剂量升级研究.
- 患者接受了IPH5201单一治疗 (100-3000毫克Q3W) 或IPH5201 (300-3000毫克Q3W) 加上杜尔瓦卢马布 (1500毫克Q3W).
- 主要终点:安全性和耐受性;次要终点:抗瘤活性,药理动力学和免疫性.
主要成果:
- 38名患者接受IPH5201单一治疗,19名患者接受IPH5201+杜尔瓦卢马布.
- 最常见的癌症:胰腺癌,非小细胞肺癌,结直肠癌.
- 与治疗相关的不良反应包括输液反应和疲劳;最大耐受剂量未达到. 在40. 4%的患者中,病情稳定.
- 在5/7的患者中,IPH5201显示出线性药理学特征,并降低了内CD39ATPase活性.
结论:
- 在药理活性剂量下,IPH5201单独或与杜尔瓦卢马布一起耐受良好.
- 治疗减少了内CD39酶的活性.
- 初步证据表明,在晚期固体瘤患者中,可能会稳定疾病.
更多相关视频
07:25In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
17.8K
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
3.5K
相关概念视频
Tumor Immunotherapy
659
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
659
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
230
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
230
