基于血液的脂质体质量评分用于缺血性中风的风险
Iolanda Lázaro1,2,3, Leila Luján-Barroso4, Natalia Soldevila-Domenech1
1Hospital del Mar Medical Research Institute, Barcelona, Spain.
European stroke journal
|September 3, 2025
概括
基于红细胞脂肪酸 (RBC-FA) 的新脂质量评分与缺血性中风风险降低有关. 较高的LFQ分数表明饮食质量更好,中风发生率更低.
科学领域:
- 营养流行病学
- 生物标志物
- 预防心血管疾病
背景情况:
- 饮食质量不佳是缺血性中风的重要危险因素.
- 红细胞脂肪酸 (RBC-FA) 作为饮食模式的可靠,长期指标.
- 研究用于评估中风风险的新生物标志物对公众健康至关重要.
研究的目的:
- 通过使用红细胞FAs开发和验证基于血液的脂质体质量 (LFQ) 评分.
- 确定LFQ得分与缺血性中风风险之间的关联.
主要方法:
- 在EPIC-西班牙队列中进行了一项病例控制研究.
- 在438例缺血性中风病例和438例匹配对照中分析了红细胞脂肪酸 (RBC- FA).
- 对有益和有害的RBC-FA应用了评分系统来得出LFQ评分,在Framingham后代研究中得到了验证.
主要成果:
- 每增加1个单位的LFQ得分与缺血性中风的几率比率 (OR) 降低0. 86 (95% CI: 0. 77- 0. 95).
- 与最低类别 (0-3分) 相比,LFQ得分最高的个体出现缺血性中风的几率明显较低.
- 在Framingham后代研究中的验证证实了这些发现,风险比率 (HR) 为每单位增加0.83和最高LFQ类别的HR显着较低.
结论:
- 基于血液的LFQ评分是评估与缺血性中风风险相关的饮食质量的有希望的生物标志物.
- 较低的LFQ得分与发展缺血性中风的风险显著相关.
- 这项研究突显了使用红细胞FA开发心血管疾病风险预测的可用工具的潜力.
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