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破坏Siglec介导的相互作用以开发用于癌症治疗的免疫疗法

Heinz Läubli^1,2, Ajit Varki^2,3

¹Laboratory for Cancer Immunotherapy, Department of Biomedicine, University of Basel, Switzerland, and Division of Oncology, University Hospital Basel, Switzerland.

Expert opinion on therapeutic targets

|September 3, 2025

概括

向与酸结合的免疫球蛋白类莱克 (Siglec) 相互作用可以克服癌症免疫疗法耐药性. 在早期临床试验中,破坏这些途径有望增强抗瘤免疫力并改善患者的结果.

科学领域:

免疫学
癌症学
葡萄糖生物学

背景情况:

癌症免疫疗法已经进步,但患者的反应受到抵抗和免疫抑制瘤微环境的限制.
含有酸的甘氨酸和Siglec受体在癌症中介导免疫抑制相互作用.
激活性Siglecs提供了一个潜在的策略来增强抗瘤免疫力.

研究的目的:

审查临床前证据,以了解糖与Siglec在癌症免疫抑制中的作用.
概述针对这一轴的治疗策略,以改善癌症免疫治疗.
讨论正在进行的早期临床试验,评估这些干预措施.

主要方法:

在癌症中对西洛甘- 西格莱克相互作用的临床前研究的综述.
针对酸-西格莱克通路的治疗策略的分析.
目前早期临床试验数据的概述.

主要成果:

临床前数据强烈支持西洛甘与西格莱克在癌症中的免疫抑制作用.
通过改变瘤微环境,破坏这些相互作用可能会显著增强癌症免疫疗法.
早期的临床试验正在研究这些相互作用的有效性.

结论:

向酸与Siglec的相互作用是克服抗癌免疫疗法的有希望的策略.
需要进一步研究以充分阐明生物机制,并确定受益最大的患者群体.
正在进行的临床试验对于验证治疗潜力和为未来的治疗策略提供信息至关重要.

关键词:

癌症免疫疗法抗体治疗葡萄糖免疫检查点乳清素酸的使用化

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