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Updated: Sep 9, 2025

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

Published on: November 22, 2024

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准二维基因酶和泛基因通路调节剂,以增强对细菌感染的宿主防御

John Santelices1, Alexander Schultz1, Alyssa Walker1

  • 1Microbiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.

mBio
|September 3, 2025
PubMed
概括

这项研究表明,用AZ-1化合物向宿主二化酶 (DUBs) 可以增强细胞内抗生素耐药细菌的清除. AZ-1提供了一种针对抗药性病原体的新型宿主导治疗方法.

关键词:
其他病原体沙门氏菌USP25 抑制剂AZ-1抗微生物耐药性 (AMR)细菌感染脱化酶 (DUB)主体向治疗 (HTT)免疫调节大细胞的反应无素蛋白酶系统 (UPS)

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