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感染SARS-CoV-2变种的叙利亚仓鼠的异性嗅觉功能障碍和鼻腔组织病理

Takeshi Saito¹, Marina Hosotani Saito², Rachel A Reyna¹

¹Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.

Microbiology spectrum

|September 3, 2025

概括

不同的SARS-CoV-2变种会导致不同程度的嗅觉功能障碍和鼻腔组织损伤. 与较早的病毒株相比,Omicron和Delta变种引发了较轻的症状和较少的伤害,为COVID-19的后果提供了洞察力.

科学领域:

病毒学
免疫学
病理学

背景情况:

嗅觉功能障碍 (OD) 是SARS-CoV-2感染的重要影响生活质量的症状.
对于开发COVID-19后果治疗策略至关重要的是了解变种对OD和鼻腔病理的影响.

研究的目的:

在叙利亚仓鼠中调查不同SARS-CoV-2变种 (武汉,阿尔法,贝塔,马,三角形,奥米克朗) 的嗅觉功能障碍和鼻腔组织病理的变异性.
将嗅觉功能与组织学发现和鼻组织中的病毒抗原存在相关.

主要方法:

叙利亚仓鼠感染了6种SARS-CoV-2变种.
使用埋藏食物检测测试来评估嗅觉功能.
通过病理检查,检测到鼻子组织 (侧).

主要成果:

武汉,阿尔法,贝塔和玛变种导致严重的过量摄入和嗅觉上皮损伤.
德尔塔和Omicron变异导致了较轻的OD和微小到轻微的鼻子组织损伤.
在所有变种感染中,在上皮细胞中检测到病毒抗原.

结论:

SARS-CoV-2 变种表现出明显的嗅觉功能障碍和鼻腔病理.
与早期变种相比,奥米克朗和三角形变种对嗅觉功能和鼻子组织的损害较小.
调查结果提供了有关OD病变的见解,并指导了COVID-19相关的嗅觉后果的治疗发展.

关键词:

冠状病毒动物模型行为测试哈姆斯特工厂组织病理学嗅觉功能障碍

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