模拟目标试验的观察性研究的透明报告-TARGET声明
Aidan G Cashin1,2, Harrison J Hansford1,2, Miguel A Hernán3,4,5
1Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia.
JAMA
|September 3, 2025
概括
模拟目标试验的观察性研究的新透明报告 (TARGET) 指南有助于研究人员报告模拟随机试验的观察性研究. 这提高了基于观察数据的因果关系估计的透明度和解释性.
科学领域:
- 流行病学
- 生物统计学
- 卫生研究方法
背景情况:
- 当随机试验不可行时,观察性研究对于因果推断至关重要.
- 模拟目标试验的观察性研究现有的报告实践缺乏标准化.
- 需要明确的指导来确保这些研究的透明度和可靠性.
研究的目的:
- 为模拟假设实用随机试验 (目标试验) 的观察性研究制定基于共识的报告准则.
- 通过提供标准化的报告框架,提高健康研究的质量和透明度.
主要方法:
- 使用EQUATOR框架制定了模拟目标试验的观察性研究透明报告 (TARGET) 准则.
- 方法包括系统审查,专家调查,共识会议和利益相关者试点测试.
- 该指南的制定涉及18名专家和108名利益相关者的反,
主要成果:
- 制定了一个21项的TARGET检查清单,分为六个部分:摘要,介绍,方法,结果,讨论和其他信息.
- 关键建议包括确定该研究为目标试验模拟,明确因果问题和方案,并报告因果估计和敏感性分析.
- 检查清单指导报告对平行组,个别随机目标试验模拟与基线混调整.
结论:
- 该指南旨在提高模拟目标试验的观察性研究的透明度和同行评审.
- 遵守TARGET清单将有助于研究人员,临床医生和读者更好地解释和应用这些研究的结果.
- 这种标准化的报告将增强观察性研究在健康研究中的有用性.
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