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Updated: Sep 9, 2025

Chemical Dimerization-Induced Protein Condensates on Telomeres
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端粒SUMO水平影响APB形成路径和ALT效率的选择

Rongwei Zhao1, Xiaoyang Yu1, Tafadzwa Chigumira1

  • 1Department of Biology, Carnegie Mellon University, Pittsburgh, PA, USA.

The Journal of cell biology
|September 3, 2025
PubMed
概括

替代延长端粒 (ALT) 途径癌症通过新核或融合形成与ALT相关的PML体 (APB). 高水平的SUMO促进APB核和增强ALT活动以维持端粒.

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