过量添加方法提高了细胞毒药物的人力资源效率和环境可持续性
Marie Kroemer1, Guillaume Galy1, Severine Tarun-Coquoz2
1Department of Pharmacy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
概括
新的半装袋用于细胞毒药物制备,大大减少了制备时间和浪费. 虽然初始成本增加了,但这种方法为化疗生产提供了更可持续的方法.
科学领域:
- 癌症学
- 制药科学
- 医疗管理
背景情况:
- 癌症发病率的增加增加了对细胞毒药物制剂的需求.
- 优化细胞毒药物制备过程对于效率和可持续性至关重要.
研究的目的:
- 评估使用特别设计的过度填充容量的半装袋对制备时间,资源利用,成本和环境可持续性的影响.
- 将"多余容量添加"方法 (半装袋) 与传统的"容量替代"方法 (装袋) 进行比较.
主要方法:
- 在一所大学医院的化疗生产部门进行了两次6个月的回顾性研究.
- 第一个阶段采用用装满袋子的体积替代方法 (5527种制剂).
- 第二期采用过量添加方法,使用半装袋 (5108种制剂),包括药物制和重力测量.
主要成果:
- 与体积替代 (3. 2分钟; p < 0. 0001) 相比,使用多余体积添加方法的中位准备时间显著缩短.
- 据估计,这节省了67个小时,相当于全职技术人员的9.8%.
- 然而,由于新袋的成本较高,每种制剂的平均成本增加了58%,而细胞毒性废物每年减少了2.21%.
结论:
- 使用半装袋的多余体积添加方法显著减少了细胞毒药物制备时间.
- 这种方法还有助于减少耗材和废物,为环境带来好处.
- 尽管初始成本增加,但效率提升和废弃物减少为其在化疗生产中的采用提供了令人信服的理由.
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