相关实验视频

Updated: Sep 9, 2025

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches

A Swimming-Induced Zebrafish Exercise Apparatus for Versatile Training Approaches

Published on: October 18, 2024

通过MASH分辨率指数定义的有氧运动训练导致MASH分辨率

Theja Channapragada¹, Sarah Batra², Breianna L Hummer^2,3

¹Department of Medicine, Penn State Health-Milton S. Hershey Medical Center, Hershey, PA, USA.

Digestive diseases and sciences

|September 3, 2025

概括

运动训练显著改善了与代谢功能失调相关的脂肪性肝病 (MASH) 的解决. 这种干预导致MASH解决率高于标准护理,按MASH解决指数 (MASH-RI) 衡量.

科学领域:

肝病学
代谢疾病
运动生理学

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASH) 影响着相当一部分人群.
建议进行体育训练,但其对肝脏组织学的影响与体重减轻无关.
非侵入性生物标志物越来越多地用于评估肝脏组织学,需要验证MASH分辨率指数 (MASH-RI) 等复合分数.

研究的目的:

使用MASH分辨率指数 (MASH-RI) 调查运动训练是否能改善MASH组织学.
评估运动训练在独立于体重减轻的MASH解决方案中的有效性.
评估MASH-RI作为对炼干预反应的肝脏组织学替代品.

主要方法:

对NASHFit试验进行了后期分析.
经过活检证明MASH的成年人被随机分配到中等强度有氧运动或标准护理20周.
用MASH分辨率指数 (MASH-RI) 来测量肝脏生物标志物的变化,并比较不同组的结果 (n=23).

主要成果:

在33%的参与者中,运动训练导致MASH解决,而在标准治疗组中为13% (p<0. 01).
接受运动训练的参与者达到MASH解决的频率几乎是三倍.
运动训练导致MASH-RI中的个体生物标志物改善,包括ALT,AST和MRI-PDFF.

结论:

运动训练是一种有效的干预措施,
MASH分辨率指数 (MASH-RI) 证明了MASH分辨率的有用性.
需要进行进一步的研究,以优化MASH-RI用于监测对生活方式干预的治疗反应.

关键词:

有氧运动 MASH解决方案指数与代谢功能障碍相关的脂肪肝炎与代谢功能障碍相关的脂肪性肝病

更多相关视频

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice

Published on: March 15, 2019

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement

A Real-World High-Intensity Interval Training Protocol for Cardiorespiratory Fitness Improvement

Published on: February 22, 2022

相关概念视频

Exercise and Muscle Performance

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

Exercise and Cardiac Output

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...

Mass Analyzers: Overview

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...