肺移植后重症监护室患者的营养支持与临床结果之间的关系:一项回顾性研究
Malika Udagedara1,2, Katherine J P Schwenger1, Yasaman Ghorbani1,3
1Department of Medicine, Toronto General Hospital, University Health Network, Toronto, Canada.
肺移植患者的蛋白质摄入量较高与重症监护室 (ICU) 停留时间较长有关. 这一效应因疾病的严重程度而变化,突出了对这些重症患者个性化的营养计划的需要.
科学领域:
- 危急护理医学
- 移植医学
- 营养科学
背景情况:
- 实体器官移植后的结果受到营养状况的显著影响.
- 肺移植 (LTx) 患者在重症监护室 (ICU) 的能量和蛋白质摄入量数据有限.
研究的目的:
- 检查机械通风后成年LTx患者的医学营养治疗和临床结果.
- 调查营养,特别是蛋白质和能量摄入量与治疗结果 (如ICU停留时间) 之间的关系.
主要方法:
- 在ICU接受机械呼吸的100名成年LTx后患者的回顾性研究 (2022-2023年).
- 在ICU住院的前14天记录了临床和营养参数.
- 使用威尔科克森等级总和测试,费舍尔精确测试和多变量分析来确定ICU LOS的预测因素.
主要成果:
- 接受每天> 1.2 g/ kg 蛋白质的患者经历了长时间的ICU和医院LOS.
- 能量摄入量和整体营养状况没有影响LOS.
- 没有发现与死亡率或感染率的显著关联.
- 多变量分析显示蛋白质摄入量与疾病严重程度 (APACHE评分) 之间有显著的相互作用,影响了ICU LOS.
结论:
- 临床治疗后重症患者摄入较高的蛋白质与更长的ICU和医院LOS有关.
- 疾病的严重程度改变了蛋白质摄入对ICU LOS的影响.
- 个性化营养策略对于优化这一高危人群的结果至关重要.
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