Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Preclinical Development: Overview01:28

Preclinical Development: Overview

4.8K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Loneliness, affectivity and psychological distress in people living alone during the COVID-19 pandemic: a cluster analysis.

Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS·2026
Same author

Epidemiology of Acute Chagas Disease in the Amazon: Association between the açaí production chain and case reports in Pará state, Brazil.

Revista da Sociedade Brasileira de Medicina Tropical·2026
Same author

Positive expectations and health behaviors among the adult population: A systematic review and meta-analysis.

Journal of health psychology·2026
Same author

Ascorbic Acid Prevents Efavirenz-Induced Anxiety-Like Behavior and Brain Oxidative Stress in Zebrafish.

Oxidative medicine and cellular longevity·2025
Same author

Anxiety and Fryes: A Novel Model to Study Anxiety in Zebrafish Larvae.

Zebrafish·2025
Same author

Do stress hormones influence choice? A systematic review of pharmacological interventions on the HPA axis and/or SAM system.

Social cognitive and affective neuroscience·2024

相关实验视频

Updated: Sep 9, 2025

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K

在动物临床前研究中Ayahuasca的影响:系统性审查

A Walsh-Monteiro1, S Morato2, F A R Uribe3

  • 1Laboratório de Neuroquímica e Comportamento, Coordenação de Ciências Biológicas, Campus Tucuruí, Instituto Federal do Pará, Tucuruí, PA, Brasil.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica
|September 3, 2025
PubMed
概括

艾亚瓦斯卡 (Aya) 显著改变动物的运动和认知行为,特别是影响血清激素系统. 需要更多标准化的临床前研究来评估其治疗安全性和神经化学效应.

更多相关视频

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.8K
Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies
03:11

Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies

Published on: June 7, 2024

808

相关实验视频

Last Updated: Sep 9, 2025

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.1K
Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.8K
Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies
03:11

Author Spotlight: Standardized Herbal Decoction Protocol for Enhanced Animal Studies

Published on: June 7, 2024

808

科学领域:

  • 神经科学
  • 药理学
  • 精神病学

背景情况:

  • 亚亚瓦斯卡 (Aya) 是一种具有潜在治疗用途的精神活性亚马逊酒.
  • 在对人进行试验之前,临床前研究对于了解其效果和安全性至关重要.

研究的目的:

  • 系统地审查阿雅华斯卡 (Aya) 对动物模型的行为和神经化学的影响.
  • 发现目前Aya临床前研究的缺陷.

主要方法:

  • 系统审查来自主要科学数据库的2359份文件 (2012-2022年).
  • 遵守PRISMA协议和Cochrane手册进行严格的研究选择.
  • 包含符合预先定义的最终分析标准的14篇文章.

主要成果:

  • 艾亚瓦斯卡 (Aya) 诱导动物运动和认知功能的显著变化.
  • 观察到的行为变化与血清激素系统有关.
  • 这些影响可能与抑郁症和精神分裂症的症状有关.

结论:

  • 在动物模型中显示出显著的行为和神经化学效应.
  • 需要更多的方法标准化临床前研究.
  • 需要进一步研究以更安全地评估Aya的治疗潜力.