睡眠呼吸暂停的患病率和临床影响
Shahid Karim1,2, Anwar Chahal1,2,3,4, Shreyas Venkataraman5
1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
JAMA cardiology
|September 3, 2025
概括
睡眠呼吸障碍 (SDB) 在缩性心肌病 (HCM) 患者中很常见,与心脏重塑的恶化和升的素T有关. 治疗SDB可能会改善HCM的结果.
科学领域:
- 心脏病学
- 睡眠医学
- 遗传学
背景情况:
- 睡眠呼吸障碍 (SDB) 通过低氧化和自主功能障碍导致心血管疾病.
- 超性心肌病 (HCM) 患者可能会增加SDB风险,但其影响尚不清楚.
研究的目的:
- 确定HCM患者中SDB的患病率.
- 调查SDB,心声学发现和心脏生物标志物之间的关联.
主要方法:
- 在154名成年HCM患者中进行前性队列研究.
- 用于诊断和分类SDB.
- 评估心声图,心电图和心脏生物标志物,并对SDB结果进行失明.
主要成果:
- 在59.1%的HCM患者中诊断出SDB.
- 与较高的左心室质量指数,E/e'比率和素-T水平相关的SDB.
- 在SDB患者中,NYHAII/ III类症状,高血压和糖尿病更为常见.
结论:
- 未诊断的SDB在HCM中非常普遍.
- SDB与不良的心肌重塑,腹功能障碍和亚临床损伤有关.
- 需要对HCM的SDB治疗进行进一步试验.
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