在帕金森病中与谷氨酸相关的研究:文献计量分析
Yan-Jun Chen1,2, Ming-Rong Xie3, Sheng-Qiang Zhou2
1Graduate School of Hunan University of Chinese Medicine, Changsha, China.
Frontiers in aging neuroscience
|September 3, 2025
概括
这项研究分析了帕金森病 (PD) 和谷氨酸研究,确定了像α-synuclein和神经炎症等关键领域的未来方向. 全球合作推动了了解病变的进展.
科学领域:
- 神经科学
- 神经退行性疾病
- 神经药理学
背景情况:
- 帕金森病 (PD) 是一种流行的神经退行性疾病.
- 谷氨酸是一种刺激性神经递质,
- 谷氨酸水平,受体功能和输送活性的失衡与PD病理有关.
研究的目的:
- 探索帕金森病 (PD) 和谷氨酸的研究热点和前沿.
- 确定PD和谷氨酸研究的未来发展方向.
- 提供研究领域的文献分析.
主要方法:
- 从科学网络 (2001-2024) 中对2,488篇出版物的图书统计分析.
- 使用CiteSpace,VOSviewer和bibliometrix进行可视化和定量评估.
- 确定主要的国家,机构,作者,期刊和关键词.
主要成果:
- 美国领先于中国,意大利,英国和法国的重要合作.
- 关键的研究领域包括基底,氧化应激,多巴胺 (DA),神经元,α-synuclein (a-Syn),谷氨酸受体和突触可塑性.
- 阿尔法-同核素 (a-Syn) 和神经炎症最近显示出强烈的研究活动和爆发力.
结论:
- 关于PD和谷氨酸的研究集中在老年人群中,强调国际和机构合作.
- 已确立的研究热点包括基底,氧化应激,DA,神经元,a-Syn,谷氨酸受体和突触可塑性.
- 未来的研究很可能集中在阿尔法-同核素 (a-Syn) 和帕金森病中的神经炎症上.
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