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Updated: May 11, 2026

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空间异质性揭示了预测肝细胞癌治疗反应和临床结果的进化特征

Shangyi Luo1, Li Liu1, Yang Sun2

  • 1Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou, Fujian, China.

Frontiers in bioinformatics
|September 3, 2025
PubMed
概括

肝细胞癌 (HCC) 的瘤内异质性可以预测患者的结果. 开发的HCC进化特征 (HCCEvoSig) 提供可靠的预后信息,并预测HCC患者的治疗反应.

关键词:
表达的动态肝细胞癌多区域测序预测情况瘤的演变

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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...