在羊群中通过向ACSL4 / NF-κB轴引发的铁和炎症
Zimeng Ma1,2, Shuo Yan1,2, Huimin Zhang1,2
1Research Center for Animal Genetic Resources of Mongolia Plateau, College of Life Sciences, Inner Mongolia University, Hohhot, China.
Frontiers in veterinary science
|September 3, 2025
概括
暴露于会通过破坏线粒体功能并触发铁灭亡来损害肠道. 八酸通过向ACSL4来减少炎症和氧化应激,显示出治疗潜力.
科学领域:
- 环境毒理学环境毒理学
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
背景情况:
- 是一种有毒的环境污染物,会造成肠道损伤.
- 了解的致病机制对于有效治疗至关重要.
研究的目的:
- 为了研究羊的诱导的乳房功能障碍,使用多种omics.
- 为了探索酸的干预机制.
主要方法:
- 多组学 (转录组学和蛋白组学) 分析.
- 表型和本病理学评估.
- 研究分子信号通路 (ROS,铁,NF-κB).
主要成果:
- 暴露损害了肠道屏障功能,并导致了他的病理变化.
- 破坏了线粒体的功能,导致氧化应激和铁亡.
- 铁亡蛋白调节NF-κB信号传递,加剧炎症.
- 酸通过结合ACSL4抑制了铁亡,减少了氧化应激和炎症.
结论:
- ACSL4/NF-κB轴是诱导的肠道病理的核心.
- 八酸在引起的肠炎症中显示出治疗潜力.
相关概念视频
01:16Necrosis
4.8K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.8K
02:26NF-κB-dependent Signaling Pathway
7.8K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.8K