结合疗法可降低晚期肝细胞癌的跨动脉化学栓塞耐药性
Hu-Yu Jiao1, Xin-Mei Yan1, Jun-Xin Li1
1Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.
World journal of clinical oncology
|September 3, 2025
概括
将免疫疗法和向药物添加到跨动脉化学栓塞 (TACE) 中,可显著降低耐药性并改善晚期肝癌 (HCC) 的存活率. 这种组合疗法是肝细胞癌的新标准治疗方法.
科学领域:
- 肝细胞癌 (HCC) 研究
- 癌症免疫疗法
- 分子向治疗
背景情况:
- 超动脉化血栓化 (TACE) 是晚期肝细胞癌 (HCC) 的首要治疗方法.
- 瘤对TACE的耐药性是一个重要的临床挑战.
- 结合TACE与编程细胞死亡 (连接体) 1 [PD- L] 抑制剂和分子向疗法 (MTT) 可以克服耐药性.
研究的目的:
- 评估TACE与PD- L) 1抑制剂和MTT结合的疗效.
- 为了比较结合治疗与TACE单一治疗在晚期HCC的结果.
- 确定组合疗法是否降低TACE耐药性并改善患者的存活率.
主要方法:
- 对721名晚期HCC患者的回顾性分析.
- 通过对比72对符合特征的患者.
- 治疗组包括TACE单独与TACE加PD- L) 1抑制剂和MTT.
- 在三个治疗周期后评估瘤进展.
主要成果:
- 组合治疗组显示出明显较低的TACE耐药率 (9. 7%与38. 8%相比).
- 在组合组中,无进展的存活时间被延长了 (17. 5个月与9. 1个月).
- 组合治疗组的整体存活率也有所改善 (20. 8个月 vs 16. 4个月).
结论:
- 将免疫疗法和向药物添加到TACE中可以显著降低晚期HCC的治疗耐药性.
- 组合治疗明显改善了无进展和整体存活率.
- 这种方法可能是治疗晚期肝癌的新标准.
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