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解读胃结环细胞癌的预后标志物:人体表皮生长因子受体2和其他关键因素

Noura Atef A Ebrahim¹, Moamen O Othman², Neveen S Tahoun³

¹Department of Oncologic Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt. npathologist@gmail.com.

World journal of clinical oncology

|September 3, 2025

概括

胃环细胞癌 (SRCC) 是一种侵袭性疾病,晚期,高瘤标志物和淋巴血管侵袭预示着不良结果. HER2阳性和手术干预影响生存率.

科学领域:

癌症学
胃肠病学
病理学

背景情况:

胃环细胞癌 (SRCC) 是一种具有不良预后的侵袭性胃癌亚型.
它的透模式和分子变异性使早期诊断和有效管理复杂化.
确定可靠的预后标记对于指导SRCC患者的临床决策至关重要.

研究的目的:

研究胃SRCC的预后因素,包括人类表皮生长因子受体2 (HER2) 表达.
分析这些因素与患者生存结果之间的关联.
确定这种罕见的胃癌亚型的预后因素.

主要方法:

在2015年至2019年间诊断的100例胃SRCC病例的回顾性分析.
人口,临床和病理数据的评估,包括瘤结节转移 (TNM) 阶段和淋巴血管侵袭.
通过免疫组织化学评估人类表皮生长因子受体2 (HER2) 表达和与生存结果的相关性 (整体和无疾病生存).

主要成果:

血清碳水化合物抗原19-9和癌胚抗原水平的升高与死亡率的增加显著相关.
晚期TNM和淋巴血管侵袭是不良结果的强有力的预测因素.
HER2阳性与较高的死亡率相关 (P = 0. 00882),但没有复发 (P = 0.53);手术治疗显著改善了存活率 (P = 0. 0226).

结论:

胃SRCC是侵袭性的,晚期,瘤标志物升高和淋巴血管侵袭导致预后不佳.
虽然HER2表达不常见,但可能表明SRCC的预后更差.
外科手术在改善胃SRCC患者的生存结果方面发挥着重要作用.

关键词:

碳水化合物抗原 19-9 癌胚抗原胃癌人类表皮生长因子受体2 淋巴血管侵袭标签环细胞癌手术治疗生存情况

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