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肌肉形态对瘤结果的影响:一篇综述

Sophie Bastijns^1,2, Blanca Alabadi^3,4, Thiago Gonzalez Barbosa-Silva^5,6

¹ZAS (Ziekenhuis aan de Stroom), University Center for Geriatrics, Antwerp, Belgium.

Journal of frailty, sarcopenia and falls

|September 3, 2025

概括

癌症患者肌肉质量和密度降低与生存率降低,治疗副作用增加和生活质量降低有关. 通过运动和营养优化肌肉健康对于更好的瘤结果至关重要.

科学领域:

癌症学
肌肉生理学
放射学

背景情况:

癌症及其治疗对患者的肌肉健康有重大影响.
肌肉健康是癌症结果的关键决定因素.
在癌症患者中,肌肉质量和力量的下降是普遍存在的.

研究的目的:

系统地审查各种肌肉参数对瘤结果的影响.
确定与癌症患者预后相关的关键肌肉指标和成像技术.
综合有关肌肉健康与癌症治疗疗效与患者幸福感之间的证据.

主要方法:

在2023年4月之前进行系统的文献搜索.
包括117篇文章评估肌肉参数,如厚度,密度和骨肌肉指数.
使用成像方法包括CT,MRI,超声波和DXA.

主要成果:

骨肌肉指数和肌肉密度的降低与较低的存活率相关.
较差的肌肉健康与更高的化学毒性,手术并发症和长时间住院有关.
肌肉数量和质量下降对治疗反应和生活质量产生了负面影响.

结论:

肌肉的数量和质量显著影响瘤的结果,可能是通过肉症.
建议在治疗计划中进行整体评估,包括全面的老年诊断.
运动和营养支持可能对癌症患者产生有益影响,因此需要进一步研究潜在机制和有针对性的干预措施.

关键词:

身体组成肌肉癌症学结果麻症

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