作为糖尿病伤口治疗剂的Mitragyna speciosa的喷雾膜形成系统配方
Putri Rachma Novitasari1, Fatma Nuraisyah2, Baso Didik Hikmawan3
1Faculty of Pharmacy Universitas Ahmad Dahlan, Yogyakarta, Indonesia.
Journal of advanced pharmaceutical technology & research
|September 3, 2025
概括
这项研究开发了一种叶提取物薄膜喷雾剂,用于治疗糖尿病伤口. 4% 度的喷雾显著加速了糖尿病老鼠的伤口愈合,显示出更快的糖尿病伤口关闭的潜力.
科学领域:
- 药理学
- 伤口的愈合
- 自然产品
背景情况:
- 糖尿病性伤口是糖尿病的慢性并发症,其特点是愈合迟缓.
- 目前用于糖尿病伤口的局部治疗方法有限,需要新的配方.
- 克拉 (Mitragyna speciosa) 的叶子含有多化合物,具有潜在的治疗益处.
研究的目的:
- 开发使用天然深度溶解剂 (NADES) 的片喷雾配方.
- 评估Kratom NADES提取物薄膜在糖尿病大鼠中的治愈效果.
主要方法:
- 使用NADES提取Kratom叶子,并将提取物制成2%,3%和4%度的薄膜喷雾剂.
- 对配方喷雾剂的物理性质 (pH,粘度,干燥时间,感官特性) 和稳定性进行了分析.
- 通过测量链素诱导的糖尿病大鼠的伤口直径缩小来评估伤口愈合活性.
主要成果:
- 所有Kratom NADES提取物薄膜喷雾剂均具有可取的物理特性.
- 在第21天,4%的kratom NADES提取物薄膜喷雾显著减少了伤口直径 (83. 99± 12. 02%).
- 组织学分析显示治疗的伤口中中性粒细胞透率降低,上皮质厚度增加.
结论:
- 在糖尿病老鼠中,Kratom NADES提取物膜形成喷雾,特别是在4%度下,显示出显著的伤口愈合潜力.
- 这种配方可能提供一种新的局部方法来加速糖尿病伤口的关闭.
- 需要进行进一步的研究, 探索 kratom 提取物在伤口治疗中的治疗应用.
相关概念视频
Cholinergic Antagonists: Pharmacokinetics
1.1K
Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
1.1K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
1.7K
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
1.7K
Drug Delivery: Miscellaneous Routes
1.0K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.0K
Ophthalmic Drug Delivery Systems
244
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
244
Antifungal Agents
73
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
73


