评估肝硬度测量相关标志物,预测临床显著门性高血压病毒性肝硬化相关事件
Yan-Qiu Li1, Yong-Qi Li1, Jin-Ze Li2
1Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
World journal of hepatology
|September 3, 2025
概括
在肝硬化患者中,LSM- 血小板比率 (LPR) 有效预测肝脏相关事件 (LREs). 与LSM和LSM- 白蛋白比率 (LAR) 相比,LPR的预测性能更好,特别是在肝脏衰竭方面.
科学领域:
- 肝病学
- 胃肠病学
- 生物标志物研究
背景情况:
- 临床显著的门高血压 (CSPH) 是影响肝脏相关事件 (LREs) 的关键因素.
- 基于肝硬度测量 (LSM) 的标记可以预测LRE风险.
研究的目的:
- 评估LSM及其复合生物标志物LSM-血小板比率 (LPR) 和LSM-白蛋白比率 (LAR) 的预测价值.
- 为了比较LSM,LPR和LAR在CSPH补偿病毒性肝硬化患者中预测LREs的性能.
主要方法:
- 追溯纳入598名患有肝硬化症的补偿病毒患者.
- 考克斯回归和卡普兰-梅尔分析评估LSM,LPR和LAR作为LREs的预测因素.
- 使用ROC,决策曲线和时间依赖的AUC分析评估模型性能.
主要成果:
- 已确定LSM,LPR和LAR是LRE的独立预测因素.
- 与LAR (AUC=0. 727) 和LSM (AUC=0. 683) 相比,LPR的预测性能更好.
- 在预测肝脏衰竭方面,LPR特别有效,其表现优于LSM和LAR.
结论:
- 在补偿性病毒性肝硬化患者中,LPR是预测LREs的优质生物标志物.
- 与LSM和LAR相比,LPR在预测肝脏衰竭方面表现出更强的疗效.
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