探索与代谢功能障碍相关的脂肪肝和肠道疾病之间的相互作用:病理生理学,临床影响和新兴疗法
Said A Al-Busafi1, Ahmed Alwassief2, Ali Madian3
1Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman. busafis@squ.edu.om.
World journal of hepatology
|September 3, 2025
概括
由肠道微生物组变化引起的代谢功能障碍相关的脂肪肝病 (MAFLD) 影响全球四分之一的人口. 针对肠肝轴的干预措施有望控制MAFLD及其心脏代谢风险.
科学领域:
- 肝病学
- 胃肠病学
- 微生物组研究
背景情况:
- 与代谢功能障碍相关的脂肪肝 (MAFLD) 影响全球25%的人口,与肥胖和胰岛素抵抗有关.
- 肠肝轴是MAFLD病变的核心,肠道失调导致肝损伤,炎症和纤维化.
- 通过受微生物和胆汁酸变化的影响,MAFLD通过葡萄糖和脂质平衡受损而加剧心脏代谢风险.
研究的目的:
- 审查肠道微生物在MAFLD病变中的作用.
- 探索新的诊断生物标志物和针对MAFLD肠肝轴的治疗策略.
- 讨论MAFLD管理的挑战和未来方向.
主要方法:
- 对将MAFLD与失调,饮食和生活方式因素联系起来的流行病学研究进行审查.
- 分析新兴的诊断工具,包括微生物组衍生生物标志物和多组组.
- 对微生物群调节干预的早期临床试验数据的评估.
主要成果:
- MAFLD群体表现出与生活方式和宿主因素相关的显著肠道失调.
- 基于微生物组的诊断和干预措施,如前/前/共生药和FMT,显示出MAFLD治疗的潜力.
- 在MAFLD患者中,早期干预显示出有前途的组织学和代谢改善.
结论:
- 肠肝轴和失活性是MAFLD治疗的关键目标.
- 结合微生物群干预和生活方式改变的精准医学方法是MAFLD治疗的最佳方法.
- 需要进一步的研究来解决种族间的变异性,建立治疗算法,并克服基于微生物组的治疗的监管障碍.
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