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相关概念视频

Auditory Pathway01:15

Auditory Pathway

5.8K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.8K
Anatomy of the Ear01:16

Anatomy of the Ear

8.9K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
8.9K
The Cochlea01:13

The Cochlea

45.8K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.8K
Hair Cells01:22

Hair Cells

41.3K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
41.3K
Hearing01:31

Hearing

53.0K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
53.0K
The Auditory Ossicles01:11

The Auditory Ossicles

1.9K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
1.9K

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相关实验视频

Updated: Sep 9, 2025

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
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Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

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质膜:结构,功能及其对听力损失的影响

Panpan Bian1, Jiong Dang1, Bai-Cheng Xu1

  • 1Department of Otolaryngology-Head & Neck Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.

Frontiers in neurology
|September 3, 2025
PubMed
概括
此摘要是机器生成的。

膜对于听力至关重要. 但基因疗法等新疗法显示出有前途.

关键词:
年龄增长尾细胞基因突变听力损失听力毒性构造膜甲状腺激素

更多相关视频

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
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Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea

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Cochlear Surface Preparation in the Adult Mouse
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Cochlear Surface Preparation in the Adult Mouse

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相关实验视频

Last Updated: Sep 9, 2025

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

7.5K
Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea
12:02

Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea

Published on: January 1, 2016

56.1K
Cochlear Surface Preparation in the Adult Mouse
09:51

Cochlear Surface Preparation in the Adult Mouse

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科学领域:

  • 耳鼻喉科
  • 细胞生物学
  • 遗传学

背景情况:

  • 构造膜 (TM) 是尾中的重要细胞外基质,对于听觉处理至关重要.
  • 它在耳力学和声音放大中的精确作用对听力至关重要.
  • 听力损失背后的机制尚未完全理解.

研究的目的:

  • 检查构造膜的结构和功能.
  • 探索TM在耳力学和听觉信号放大中的作用.
  • 讨论导致TM功能障碍的因素和潜在的治疗策略.

主要方法:

  • 对构造膜结构,功能和听力损失的研究进行文献综述.
  • 对TM完整性的遗传因素,衰老和荷尔蒙影响的分析.
  • 检查当前和新兴的诊断和治疗方法.

主要成果:

  • TM 组成的异常 (原,糖氨基酸,蛋白质) 与听力损失有关.
  • 像TECTA,TECTB和CEACAM16这样的基因突变会破坏TM的完整性,导致神经感官听力损失.
  • 老龄化和甲状腺激素缺乏导致TM退化.

结论:

  • 膜完整性对于正常听力至关重要.
  • 遗传突变,衰老和荷尔蒙失衡对TM的结构和功能产生重大影响.
  • 基因疗法和干细胞疗法是未来与TM相关的听力损失的有希望的治疗方法.