对口腔状细胞癌患者不同炎症相关指标的预后值进行比较
Aoming Cheng1, Kaixiong Wei1, Qiaoshi Xu1
1Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Frontiers in genetics
|September 3, 2025
概括
炎症标志物,包括晚期肺癌炎症指数 (ALI) 和预后营养指数 (PNI),对于预测年轻男性口腔状细胞癌 (OSCC) 患者手术后的短期结果有价值.
科学领域:
- 癌症学
- 临床研究
- 生物标志物
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重大的临床挑战.
- 了解预后因素对于有效的患者管理至关重要.
- 炎症标志物越来越多地被认为对癌症的预后起作用.
研究的目的:
- 评估OSCC患者的炎症标志物的预后意义.
- 确定特定的标志物和患者小组,
- 评估这些标志物的临床实用性,以指导治疗决策.
主要方法:
- 对接受手术治疗的624名OSCC患者进行了回顾性分析.
- 收集手术前的临床和生化数据.
- 使用了卡普兰-梅尔,考克斯回归和时间依赖的ROC曲线分析.
主要成果:
- 高度炎症趋势与总生存率 (OS) 和无病生存率 (DFS) 的显著下降相关.
- 晚期肺癌炎症指数 (ALI) 和预后营养指数 (PNI) 被确定为OS的独立预测指标.
- 在60岁以下的男性患者中,ALI和PNI具有特别的预后价值,ALI显示出强大的短期预测性能 (AUC=0. 74).
结论:
- 在手术治疗的OSCC患者中,ALI和PNI是有价值的短期预后指标.
- 这些标志物对年轻男性患者 (< 60 岁) 尤为重要.
- 这些发现支持ALI和PNI在特定OSCC患者群体的风险分层和个性化治疗策略中的临床实用性.
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