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对于中国北部的pepsinogen,特定年龄和性别的动态和下一代的参考间隔

Miao-Miao Zhang¹, Dong Zhu², Hai-Bin Zhao¹

¹Department of Laboratory Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China.

World journal of gastroenterology

|September 3, 2025

概括

这项研究为pepsinogen (PG) I和II引入了下一代参考间隔,考虑到年龄和性别. 与传统方法相比,这些新RI提高了胃病的诊断准确性.

科学领域:

临床生物化学
实验室医学
胃肠病学

背景情况:

素 (PG) 和PG I/II比率 (PGR) 是诊断H. pylori,胃炎和胃癌风险的关键.
目前的参考间隔 (RIs) 通常无法解释年龄,性别和逐渐的生理变化.
下一代RI提供了更精确的解读PG水平的解决方案.

研究的目的:

研究血清PG水平的特定年龄和性别动态.
在中国北部的成人和老年人中建立下一代PG I和PG II的RI.

主要方法:

在708名健康人群中测量了血清PG水平.
使用双向ANOVA分析了PG的年龄和性别影响.
为了建模与年龄相关的趋势并创建连续的参考百分位数,使用了广义增值模型 (GAMLSS).

主要成果:

根据年龄和性别,PG I和PG II水平显著变化 (P < 0. 001),而PGR则保持稳定.
使用GAMLSS建立下一代RI,显示PG I和PG II的不同年龄依赖的轨迹.
这些下一代RI在特定年龄分组中表现出高于分区RI的准确性.

结论:

这项研究提供了第一代PG的RI,反映了特定年龄和性别的变化.
这些发现支持在实验室诊断中对PG水平的更多个性化解释.
研发的RI有助于对胃健康和相关疾病风险的评估.

关键词:

年龄动态胃生物标志物下一代参考间隔素的使用个性化医疗参考时间间隔

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