一种健康方法揭示了令人担忧的抗菌素耐药性模式:肯尼亚基西的一项横截面研究
Briton M Kavulavu1,2,3, Eric O Omwenga2, Oscar Asanya Nyangiri2
1Department of Medical Microbiology, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
PloS one
|September 3, 2025
概括
在肯尼亚的人类,动物和环境样本中,肠道细菌中存在抗菌素耐药性 (AMR). 共享的抗药性模式突出显示了相互关联的途径,强调了对抗药性监测的一种健康方法的必要性.
科学领域:
- 环境微生物学
- 公共卫生
- 传染性疾病
背景情况:
- 抗菌药物耐药性 (AMR) 构成了全球严重的健康威胁,特别是在撒哈拉以南非洲等诊断能力有限的地区.
- 肠杆菌是抗菌素耐药性的关键因素,环境储库在人类,动物和环境之间传播起作用.
研究的目的:
- 在肯尼亚的人类,水,动物便和土壤样本中调查肠道细菌的流行率和抗菌敏感性.
- 在不同样本类型中确定抗菌素耐药性模式和相关的耐药性基因.
主要方法:
- 在肯尼亚进行了一项横截面研究,采集了365个样本 (200人,55水,55动物便,55土).
- 鉴定了肠杆菌分离物,并使用盘扩散方法进行了抗菌敏感性测试.
- 进行了分子分析以检测特定的AMR基因.
主要成果:
- 在肠道细菌中观察到AMR的高患病率,特别是对piperacillin- tazobactam (高达87%) 和安皮西林 (高达79%) 的耐药性.
- 大肠杆菌是最常见的隔离物 (81. 6%). 在人类,水,动物和土壤样本中共享了耐药性模式.
- 在人类分离物中检测到blaTEM,blaOXA-48,blaSHV和blaCTXM-15等特定耐药基因,动物和环境样本的流行率有所不同.
结论:
- 在人类,动物和环境来源中共享的抗菌耐药性模式表明相互关联的AMR传播途径.
- 这些发现强调了采用"单一健康"方法进行综合抗药性监测和干预的必要性.
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