用大麻素补充HIV-ART可以增加血清素,BHB和Ahr信号,同时降低二次胆汁酸和乙醇胆
Lakmini S Premadasa1, Luis Romero1, Mahesh Mohan1
1Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Science advances
|September 3, 2025
概括
在接受抗逆转录病毒治疗 (ART) 的SIV感染中,长期服用低剂量的delta-9- tetrahydrocannabinol (THC) 补充剂改善了肠- 大脑通信,胆固醇稳定和代谢健康. 这表明大麻素可以减轻艾滋病患者的炎症和代谢功能障碍.
科学领域:
- 免疫学
- 神经科学
- 代谢科学
背景情况:
- 接受抗逆转录病毒治疗 (ART) 的HIV感染者仍面临慢性炎症和代谢问题,增加非艾滋病并发症风险.
- 持续的炎症和代谢功能障碍是长期治疗HIV的关键挑战,即使使用有效的ART.
研究的目的:
- 调查低剂量的delta-9- tetrahydrocannabinol (THC) 对感染猿类免疫缺陷病毒 (SIV) 治疗的 rhesus macaques (RMs) 的炎症和代谢功能障碍的长期影响.
- 在艾滋病毒感染和ART的背景下探索THC对肠-大脑通信,胆固醇平衡和心血管健康标志物的影响.
主要方法:
- 长期使用低剂量THC治疗SIV感染的 rhesus.
- 分析血和膜样本以检测血清,甲,胆固醇,二次胆酸 (SBA) 和β-甲酸 (BHB) 的变化.
- 评估了血清素受体 (HTR4/HTR7),亚利碳水化合物受体 (Ahr) 和大麻素受体 (CBR1/CBR2) 的表达.
主要成果:
- 通过CBR2增强了肠-大脑信号分子 (血清素,甲) 和增强了血清素受体表达.
- 通过丰富 * Oscillibacter * ,降低血胆固醇和有毒 SBA,THC 改善胆固醇平衡.
- THC通过CBR1提升了BHB水平,表明肝脏脂肪酸氧化增强,并恢复了心脏毒性长链乙胆.
结论:
- 长期服用低剂量的THC是SIV感染的安全辅助疗法.
- THC有效缓解慢性炎症和代谢功能障碍,改善肠道与大脑之间的沟通和心血管健康标志物.
- 植物性大麻素有望解决艾滋病毒感染者在ART治疗中所面临的持续健康挑战.
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