作为质子治疗中的孔径材料的Cerrobend和碳化物的放射性评估
Jia Wei Law1, Alexandre Santos2, Scott Penfold3
1School of Physics, Chemistry and Earth Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
概括
在质子疗法中,黄铜是个最佳材料. 碳化物和Cerrobend具有较低的中子剂量和可控激活的替代潜力,而则存在挑战.
科学领域:
- 医学物理
- 辐射瘤学
- 材料科学
背景情况:
- 在笔光束扫描 (PBS) 质子疗法中,患者特定的孔径增强了目标合规性,但增加了中子产生和孔径激活.
- 铜是这些孔径的标准材料,但正在探索具有成本效益的替代品,如Cerrobend和碳化物.
研究的目的:
- 评估Cerrobend和碳化物作为PBS质子治疗孔口的材料.
- 使用TOPAS模拟,将这些材料的二次中子产生和激活与黄铜和-合金进行比较.
主要方法:
- 使用粒子模拟工具 (TOPAS) 模拟开口的230 MeV质子束辐射.
- 在水幻影中评分中子流动性和剂量,并使用自定义脚本计算同位素形成和残留活性.
主要成果:
- 的二次中子剂量是最低的. 与黄铜相比,碳化物和Cerrobend的中子剂量等价值分别低10%,高28%.
- 在6周的治疗过程中,Cerrobend和碳化物表现出相似的激活效果,比黄铜激活效果高1. 4倍.
- 在治疗后的30天和130天,Cerrobend和碳化的残留活性下降到低于黄铜水平. 尼克尔的长期残留活性很高.
结论:
- 由于其中子生成和激活性质的平衡,铜仍然是PBS质子疗法开口的首选材料.
- 碳化和Cerrobend是可行的替代品,提供潜在的成本效益和可接受的性能.
- 的高残留活性使其不太适合用于质子治疗中的动态聚合系统 (DCS).
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