对尾环细胞腺癌的治疗方法的有效性
Hoe Yan Hor1, Melody Pi Yin Tu1, Arshia Pessaran1
1Division of Surgical Oncology and Endocrine Surgery, Mayo Clinic, Arizona, 5777 E. Mayo Blvd. Phoenix, AZ, 85054, USA.
American journal of surgery
|September 3, 2025
概括
标签环细胞腺癌 (SRCA) 的治疗仍然具有挑战性. 细胞减少手术与高热腹膜内化疗 (HIPEC) 提供了对尾SRCA的最佳生存结果,优于全身治疗.
科学领域:
- 胃肠道瘤学
- 外科瘤学
- 罕见的癌症
背景情况:
- 尾细胞腺癌 (SRCA) 是一种罕见的恶性瘤.
- 与预后不佳和治疗指导方针有限相关.
- 关于尾性SRCA最佳管理策略的现有数据很少.
研究的目的:
- 评估尾环细胞腺癌患者的治疗结果.
- 确定预后因素和最佳的手术和全身治疗策略.
- 评估细胞减小手术和高热腹腔内化疗 (HIPEC) 在治疗SRCA中的作用.
主要方法:
- 在1998年至2024年期间诊断出SRCA的84名患者的回顾性评估.
- 对患者人口统计,瘤特征,治疗方法和生存数据的分析.
- 基于治疗干预措施的生存结果比较,包括细胞减小手术和HIPEC.
主要成果:
- 大多数SRCA瘤是高度 (81%) 和转移性疾病 (69%).
- 完整的细胞减少提供了最佳的5年生存率 (25%),而全身治疗并没有显著改善.
- 超热腹腔内化疗 (HIPEC) 添加到细胞减小手术中,显示了改善5年生存率的趋势 (20% vs 5%, p=0. 059).
结论:
- 结合HIPEC的细胞削减手术显示出对尾SRCA最有利的生存结果.
- 系统化疗没有显著改善这一组患者的存活率.
- 尾性SRCA的总体结果仍然很差,因此需要开发新的治疗方法.
更多相关视频
08:51Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
10.1K
09:48An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
8.2K
相关概念视频
Appendicitis-II: Diagnostic Studies and Management
145
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
145
Appendicitis-I: Introduction
614
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
614
