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Updated: Sep 9, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

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在p53信号传递中对USP28细胞功能的药理查询

Ariana S Bratt1, Susan Kilgas2, Maria I Tarazona Guzman1

  • 1Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Cell chemical biology
|September 3, 2025
PubMed
概括

研究人员开发了CAS-010,一种针对USP28 (双化酶) 的特定抑制剂,以研究其在p53信号传递和细胞命运中的作用. 这种化学探测器有助于了解无处不在的信号通路.

关键词:
53BP1 其他美国美国化学探测器晶体结构脱化酶其他p53转录的调节

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