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Updated: Sep 9, 2025

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防止卵细胞中CpG过甲基化,保护小鼠的发育

Yumiko K Kawamura1, Evgeniy A Ozonov2, Panagiotis Papasaikas2

  • 1Friedrich Miescher Institute for Biomedical Research, 4056 Basel, Switzerland.

Developmental cell
|September 3, 2025
PubMed
概括

基因组脱甲基酶KDM2A和KDM2B防止卵细胞中异常的DNA甲基化. 这种表观遗传调节对于基因转录和成功的早期胚胎发育至关重要.

关键词:
在CpG岛上DNA 甲基化在KDM2A在KDM2B在中国聚合器胚胎发生母亲表观遗传卵子细胞重编程

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