人体血衍生的外体凝:用于通过皮肤输送甲酸的仿生载荷
Rabia Gul1, Wajeeha Khalid1, Muhammad Sarfraz2
1Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan.
Journal of drug targeting
|September 3, 2025
概括
人类血衍生外体对通过皮肤传递药物有很大希望. 外体凝增强了皮肤的透性和减少了炎症, 这表明一种新的药物输送平台.
科学领域:
- 生物材料科学
- 纳米技术
- 药理学
背景情况:
- 通过皮肤输送药物面临着低透性药物的挑战.
- 纳米级囊泡正在被用于药物输送.
研究的目的:
- 作为一种通过皮肤传递药物载体,研究人体血衍生的外体凝.
- 评估外体凝中的甲状腺 (MTX) 的加载和释放特性.
- 评估MTX载体外体凝在体内具有的抗炎作用.
主要方法:
- 通过超离心和透析从人体血中分离出外体.
- 通过冷解方法将甲基酸 (MTX) 装入外体.
- 含有MTX的外体被纳入基于carbopol 940的凝中.
- 评估了物理化学性质,药物释放,皮肤透性和抗炎活性.
主要成果:
- 带有MTX的外体的平均尺寸为162. 15nm,PDI为0. 372.
- 外体凝表现出适用于皮肤的物理化学和质性质.
- 含有MTX的外体凝显示药物释放持续 (59. 14%在72小时内) 和皮肤透率增加了三倍.
- 与MTX凝相比,体外凝和含MTX的体外凝可以减少炎症.
结论:
- 人类血衍生外体可以有效地作为药物输送载体.
- 外体凝通过改善皮肤透性并提供持续释放来增强通过皮肤传递的药物.
- 外体凝具有显著的潜力作为一种创新的跨皮疗法平台.
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