低体积与中等体积肠道制备的比较及其对工作和耐受性的影响:一个开放的,非劣势的,随机对照试验
Milou L M van Riswijk1, Fleur A Indemans2, Kimberly Hawinkels3
1Gastroenterology and hepatology, Radboudumc Afdeling Maag- Darm- en Leverziekten, Nijmegen, Netherlands.
Endoscopy
|September 3, 2025
概括
低容量肠道制剂 (1L PEG+Asc) 和高容量 (2L PEG+Asc) 在结肠镜中同样有效. 患者更喜欢低音量, 显示出更好的重复手术意愿.
科学领域:
- 胃肠病学
- 临床试验
- 患者的结果
背景情况:
- 肠道准备对于结肠镜检查至关重要,
- 低量药可能会改善耐受性,但它们对患者报告的结果的影响需要进一步研究.
研究的目的:
- 为了比较小容量 (1L PEG+Asc) 与中等容量 (2L PEG+Asc) 肠准备剂的疗效和患者报告的结果.
- 评估1L PEG+Asc与2L PEG+Asc在适当的肠道清洁方面没有劣势.
主要方法:
- 在四个荷兰医院进行了一项非劣势性随机试验.
- 患者接受了2L的PEG+Asc或1L的PEG+Asc与硫酸.
- 准备前后通过验证的问卷评估了生产力,耐受性和与健康有关的生活质量 (HRQoL).
主要成果:
- 1L的PEG+Asc与2L的PEG+Asc不相差,其足够的清洗率为96. 1%和96. 4%.
- 在1L PEG+Asc组中,愿意重复治疗的患者数量显著增加 (59. 9% vs 48. 3%).
- 耐受性是重复愿意的最有影响的因素;没有观察到HRQoL,缺勤率或工作生产率的显著差异.
结论:
- 低容量肠道制剂 (1L PEG+Asc) 是中等容量制剂 (2L PEG+Asc) 的可行替代品,其清洁效果不劣.
- 较少量剂的耐受性提高了患者重复检查的意愿,可能减少了结肠镜检查的障碍.
- 耐受性是影响患者服从和重复结肠镜检查的关键因素.
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