癌症治疗耐药性的非编码RNAs-glycolysis轴:对治疗溶液的机制的洞察
Jiachen Tan1, Qinzheng Xu2, Nuruliarizki Shinta Pandupuspitasari3
1School of Medicine, Nantong University, Nantong 226001, China.
Biochemical pharmacology
|September 3, 2025
概括
癌细胞通过改变糖分解来抵抗治疗,这种过程由信号分子和非编码RNAs (ncRNAs) 调节. 草药可以通过向ncRNA- glycolysis轴来克服这种抵抗.
科学领域:
- 癌症学
- 分子生物学
- 生物化学
背景情况:
- 抗癌疗法是一个主要的临床障碍,通常与代谢重编程有关,特别是癌细胞中的功能障碍糖解.
- 关键的信号分子 (EGFR,HIF-1α,AMPK,β-catenin) 和非编码RNA (ncRNA) 如miRNA,lncRNA和circRNA参与调节糖分和调解治疗耐药性.
研究的目的:
- 审查ncRNA及其调节网络在癌症糖解和耐药性的作用.
- 探索针对ncRNA糖解轴的潜力,以克服癌症治疗的抵抗力.
主要方法:
- 专注于研究ncRNA,糖解和癌症药物耐药性的文献综述.
- 调节机制的分析,包括竞争性内源性RNA (ceRNA) 网络和外体的ncRNA.
- 检查草药对癌症中ncRNA糖解轴的影响.
主要成果:
- 包括miRNAs,lncRNAs和circRNAs在内的ncRNAs显著调节癌症糖解和耐药性.
- ceRNA 网络 (circRNA/lncRNA-miRNA-mRNA) 和外体 ncRNA 在调节糖解路径和调解耐药性方面至关重要.
- 某些miRNA可以抑制或促进糖解,从而影响治疗结果.
结论:
- 这一ncRNA- glycolysis轴是癌症治疗耐药性的关键决定因素.
- 有望通过草药解决这一问题, 为克服癌症抗药性提供一个有希望的策略.
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