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对先天免疫错误的临床管理指南的范围审查
C Murray1, E Santangeli2, D Mockler3
1Department of Immunology, Galway University Hospital, Galway, Ireland.
本次对先天性免疫错误 (IEI) 临床指导方针的审查发现,最主要的重点是治疗,患者参与度有限,国际共识对常见疾病存在差距.
科学领域:
- 免疫学
- 临床实践指南
- 医疗保健研究
背景情况:
- 由欧洲免疫缺陷学会 (ESID) 临床工作组 (CWP) 委托进行范围审查.
- 该审查旨在评估现有的先天免疫错误 (IEI) 临床管理指南.
- 目的是发现差距,并为改善患者护理的指导方针提供信息.
研究的目的:
- 对IEI的临床管理指南进行全面的范围审查.
- 确定缺乏国际共识或足够的患者/多学科投入的领域.
- 在未来的指导方针制定中支持ESID CWP.
主要方法:
- 在Embase,Medline和Google学者中进行了系统的搜索.
- 搜索术语来源于2022年国际免疫学会联盟 (IUIS) 的IEI分类.
- 根据资格标准,两位独立审稿人对标题,摘要和全文进行了选.
主要成果:
- 审查了183篇出版物;大多数指南集中在IEI治疗,诊断和预防上.
- 大多数指导方针是最新的 (在5年内公布) 并在高收入国家制定.
- 发现了显著的差距,包括患者/多学科参与的有限程度以及对几个普遍的IEI缺乏国际共识.
结论:
- 该审查提供了对IEI管理的现有同行评审指南的全面概述.
- 发现的差距凸显了更具包容性和国际认可的指导方针的需要.
- 这项工作将指导未来的努力,以提高IEI的临床实践和患者结果.
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